November 21, 2014
Customized Nutritional Enhancement For Pregnant Women Appears to Lower Incidence of Certain Common Maternal and Neonatal Complications

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A retrospective chart review analyzed the effect of customized nutri- tion on the incidence of pregnancy-induced hypertension (PIH), gestational diabetes (GDM), and small-and large-for-gestational-age (SGA, LGA) neonates, examining consecutive deliveries between January 1, 2011, and December 31, 2012, at a low-risk community hospital. The population was divided into 3 groups: (1) study group (SG), (2) pri- vate practice (PP), and (3) community healthcare clinic (CHCC). All groups received standard perinatal management, but additionally the study group was analyzed for serum zinc, carnitine, total 25-hydroxy cholecalciferol (25 OH-D), methylene tetrahydrofolate reductase, and catechol-O-methyl transferase poly- morphisms in the first trimester prior to intervention, with subsequent second trimester and postpartum assessment of zinc, carnitine, and 25 OH-D after intervention. Intervention consisted of trimester-by-trimester nutrition and lifestyle education, supplementation of L-methylfolate, magnesium, essential fatty acids, and probiotics for all SG patients, with targeted supplementation of zinc, carnitine, and 25 OH-D. Because of small case occurrence rates of individual conditions in the study group, unreportable reductions were found, except GDM (SG vs CHCC, P value .046 with 95.38% confidence interval [CI]), and PIH (SG vs PP, P value .0505 with 94.95% CIl). The aggregated occurrence rate of the four conditions, however, was significantly lower in the study population than in either comparison population (PP P value .0154 with 98.46% CI, and CHCC P value .0265 with 97.35% CI). Customized nutritional intervention appears to have significantly reduced adverse perinatal outcomes Prospective study within larger, at-risk populations is needed to determine whether customized nutrition improves conditions individually.

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Posted on Nov 21, 2014